人参皂甙 Rg5
人参皂苷Rg5(Ginsenoside Rg5)
CAS: 186763-78-0
化学式: C42H70O12
| 中文名 | 人参皂苷Rg5 |
| 英文名 | Ginsenoside Rg5 |
| 别名 | 人参皂苷Rg5 人参皂苷 RG5 人参皂甙 RG5 人参皂苷RG5对照品 人参皂苷RG5标准品 人参皂苷RG5, 来源于人参 |
| 英文别名 | GinsenosideRrg5 Ginsenoside Rg5 Ginsenoside-Rg5 β-D-Glucopyranoside, (3β,12β,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-β-D-glucopyranosyl- b-D-Glucopyranoside, (3b,12b,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-b-D-glucopyranosyl- (3beta,12beta,20E)-12-Hydroxydammara-20(22),24-dien-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside (8ξ,9ξ,12α,13ξ,14β,17β)-12-Hydroxy-4,4,7,10,14-pentamethyl-17-[(2 E)-6-methyl-2,5-heptadien-2-yl]gonan-3-yl 2-O-β-D-glucopyranosyl- β-D-glucopyranoside |
| CAS | 186763-78-0 |
| 化学式 | C42H70O12 |
| 分子量 | 767 |
| 密度 | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
| 沸点 | 855.6±65.0 °C(Predicted) |
| 溶解度 | 甲醇，吡啶，DMSO |
| 酸度系数 | 12.85±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 类白色粉末 |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。 |
| MDL号 | MFCD22200429 |
| 体外研究 | Ginsenoside Rg5 plays a novel role as an IGF-1R agonist. Ginsenoside Rg5 binds to IGF-1R with an IC 50 value of ~90 and its angiogenic activity is inhibited by IGF-1R knockdown. To investigate the possible interaction of Ginsenoside Rg5 with IGF-1R, a docking analysis is performed. Docking results show that Ginsenoside Rg5 binds strongly at two sites, A and B, with K d values of 20 and 27 nM, respectively, to the cysteine-rich domain of IGF-1R. Pretreatment with Rg5 blocks the binding of radiolabeled IGF-1 to HUVECs with an IC 50 value of ~90 μM, which is greater than an IC 50 value of ~1.4 nM for unlabeled IGF-1. The results from MTT assay show that MCF-7 cell proliferation is inhibited by Ginsenoside Rg5 treatment for 24, 48 and 72 h in a dose-dependent manner. Ginsenoside Rg5 at different concentrations (0, 25, 50 and 100 μM), induce cell cycle arrest in G0/G1 phase through regulation of cell cycle-related proteins in MCF-7 cells. |
| 体内研究 | Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 and COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage and infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal and no inflammation and cast formation is observed in kidney tissues. |
| 参考资料 展开查看 | 1. 张道明 张奇 刘林林 任辉.人参皂苷Rg5通过下调Bcl-2蛋白促进食管癌Eca-109细胞凋亡[J].中国实验诊断学 2018 22(04):700-703. 2. 沈俊逸 赵智明 刘春丽 徐子涵 蔡辉.人参皂苷对大鼠脑血管内皮细胞MEG3表达的干预作用及促进血管新生的研究[J].中华中医药杂志 2019 34(08):3418-3421. 3. 刘慧颖, 王承潇, 杨野,等. 微波辅助降解三七茎叶总皂苷生成人参皂苷Rg_5的工艺研究[J]. 中草药, 2018, v.49;No.625(14):58-64. 4. 董坤园, 于澎, 熊金路,等. 基于高效液相色谱图谱结合化学计量学的红参指纹图谱研究[J]. 食品安全质量检测学报, 2019, 010(021):7316-7321. 5. 张娜,黄鑫,郭云龙,越皓,刘淑莹.基于UPLC-QQQ-MS多指标统计分析研究不同生境人参中皂苷分布[J].特产研究,2020,42(06):48-54. 6. 赵彩秀,王楠,黄鑫,越皓,郭云龙,刘淑莹.枯草芽孢杆菌JLGA-SD-28转化人参皂苷Rb1的特性及其全基因组测序分析[J].中成药,2021,43(02):518-523. 7. 邵紫君,李志满,于鹏程,陈建波,李珊珊,孙印石.氨基酸转化三七花中稀有人参皂苷及提取液对脂多糖诱导的RAW264.7细胞活性的影响[J].中草药,2021,52(03):702-710. 8. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 9. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 10. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 11. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 12. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 13. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 14. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 15. [IF=3.503] Jiajia Dong et al."Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins."Pharm Biol. 2021;59(1):653-661 16. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;: 17. [IF=6.576] Zhi-man Li et al."Transformation Mechanism of Rare Ginsenosides in American Ginseng by Different Processing Methods and Antitumour Effects."Frontiers in Nutrition. 2022; 9: 833859 18. [IF=1.885] Guo Na et al."Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis."International Journal of Analytical Ch |
人参皂甙 Rg5 - 简介
人参皂苷Rg5是从人参中提取得到的一种天然活性成分。它属于人参皂苷类化合物，其化学结构中含有多个糖苷单元。
人参皂苷Rg5具有多种生物活性，包括抗氧化、抗炎、抗肿瘤和抗疲劳等作用。这些活性使得人参皂苷Rg5在医学领域有广泛的应用。
制取人参皂苷Rg5的方法主要有超声辅助提取、酸碱水解、微波辅助提取等。这些方法能高效地提取人参中的有效成分，得到纯度较高的人参皂苷Rg5。
人参皂苷Rg5作为一种天然产物，一般认为具有较高的安全性。个人体质差异和过量使用可能导致不良反应。
人参皂苷Rg5具有多种生物活性，包括抗氧化、抗炎、抗肿瘤和抗疲劳等作用。这些活性使得人参皂苷Rg5在医学领域有广泛的应用。
制取人参皂苷Rg5的方法主要有超声辅助提取、酸碱水解、微波辅助提取等。这些方法能高效地提取人参中的有效成分，得到纯度较高的人参皂苷Rg5。
人参皂苷Rg5作为一种天然产物，一般认为具有较高的安全性。个人体质差异和过量使用可能导致不良反应。
最后更新：2024-04-09 20:45:29
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规格: SG9030-10mg,10mg
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库存: 现询
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现货供应
产品名: 人参皂苷Rg5 标准品 去供应商网站查看 询盘CAS: 186763-78-0
产地: 北京
包装: 瓶
规格: SG9030-10mg,10mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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